Quasi-local energy and the choice of reference

A quasi-local energy for Einstein's general relativity is defined by the value of the preferred boundary term in the covariant Hamiltonian formalism. The boundary term depends upon a choice of reference and a time-like displacement vector field (which can be associated with an observer) on the boundary of the region. Here we analyze the spherical symmetric cases. For the obvious analytic choice of reference based on the metric components, we find that this technique gives the same quasi-local energy values using several standard coordinate systems and yet can give different values in some other coordinate systems. For the homogeneous-isotropic cosmologies, the energy can be non-positive, and one case which is actually flat space has a negative energy. As an alternative, we introduce a way to determine the choice of both the reference and displacement by extremizing the energy. This procedure gives the same value for the energy in different coordinate systems for the Schwarzschild space, and a non-negative value for the cosmological models, with zero energy for the dynamic cosmology which is actually Minkowski space. The timelike displacement vector comes out to be the dual mean curvature vector of the two-boundary.Comment: 21 pages; revised version to appear in CQ

Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes

Abstract Diabetic retinopathy (DR) is a major cause of blindness in working adults in the industrialized world. In addition to vision loss caused by macular edema and pathological angiogenesis, DR patients often exhibit neuronal dysfunction on electrophysiological testing, suggesting that there may be an independent neuronal phase of disease that precedes vascular disease. Given the tremendous metabolic requirements of the retina and photoreceptors in particular, we hypothesized that derangements in metabolic regulation may accelerate retinal dysfunction in diabetes. As such, we induced hyperglycemia with streptozotocin in mice with monoallelic Nampt deletion from rod photoreceptors, mice lacking SIRT3, and mice lacking SIRT5 and tested multiple components of retinal function with electroretinography. None of these mice exhibited accelerated retinal dysfunction after induction of hyperglycemia, consistent with normal-appearing retinal morphology in hyperglycemic Sirt3 −/− or Sirt5 −/− mice. However, mice lacking both SIRT3 and SIRT5 (Sirt3 −/− Sirt5 −/− mice) exhibited significant evidence of inner retinal dysfunction after induction of hyperglycemia compared to hyperglycemic littermate controls, although this dysfunction was not accompanied by gross morphological changes in the retina. These results suggest that SIRT3 and SIRT5 may be involved in regulating neuronal dysfunction in DR and provide a foundation for future studies investigating sirtuin-based therapies

Waveguide cooling system

An improved system is described for cooling high power waveguides by the use of cooling ducts extending along the waveguide, which minimizes hot spots at the flanges where waveguide sections are connected together. The cooling duct extends along substantially the full length of the waveguide section, and each flange at the end of the section has a through hole with an inner end connected to the duct and an opposite end that can be aligned with a flange hole in another waveguide section. Earth flange is formed with a drainage groove in its face, between the through hole and the waveguide conduit to prevent leakage of cooling fluid into the waveguide. The ducts have narrowed sections immediately adjacent to the flanges to provide room for the installation of fasteners closely around the waveguide channel

Electro-optic scanning of light coupled from a corrugated LiNbO3 waveguide

Light diffracted from a grating output coupler in a Ti-diffused LiNbO3 waveguide is scanned electro-optically. Using a coupling length of 2.5 mm in our arrangement we have demonstrated a scanning capability of one resolved spot per 3 V/µm applied field